Cytotoxic and antimicrobial effects of biosynthesized ZnO nanoparticles using of Chelidonium majus extract
نویسندگان
چکیده
The basic goal of this study was to synthesize zinc oxide nanoparticles using the Chelidonium majus extract and asses their cytotoxic and antimicrobial properties. The synthesized ZnO NPs were characterized by UV-Vis, Scanning Electron Microscopy (SEM) with EDS profile, Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), Transmission Electron Microscopy (TEM) and Atomic Force Microscopy (AFM). The aforementioned methods confirmed that the size of synthesized ZnO nanoparticles was at the range of 10 nm. The antimicrobial activity of ZnO nanoparticles synthesized using the Ch. majus extract was tested against standard strains of bacteria (Staphylococcus aureus NCTC 4163, Pseudomonas aeruginosa NCTC 6749, Escherichia coli ATCC 25922), yeast (Candida albicans ATCC 10231), filamentous fungi (molds: Aspergillus niger ATCC 16404, dermatophytes: Trichophyton rubrum ATCC 28188), clinical strains of bacteria (Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus) and yeast (Candida albicans). The study showed that zinc oxide nanoparticles were excellent antimicrobial agents. What is more, biologically synthesized ZnO nanoparticles demonstrate high efficiency in treatment of human non-small cell lung cancer A549.
منابع مشابه
Green synthesis of zinc oxide nanoparticles by Zataria multiflora extract and evaluation of its antimicrobial, cytotoxic and apoptotic effects on HT-29 cell line
Introduction: Metal oxide nanoparticles have long been challenged as a candidate for cancer treatment. In the present study, for the first time, biosynthesis of zinc oxide nanoparticles was performed by Zataria multiflora extract and then their antimicrobial, cytotoxic and apoptotic effects on colon cancer cell lines were investigated. Materials and Methods: The zinc oxide (ZnO) nanoparticles w...
متن کاملA Quick Review of the Effects of Chelidonium majus L and Its Active Components on Health and Disease Treatment
Background: Using herbs for the treatment of diseases has a long history. Chelidonium majus from the family of Papaveraceae is one of the best-known and most widely used herbs used in traditional medicine. The aim of this study was to review its active components, as well as its therapeutic and toxic effects on body tissues. Methods: This short o...
متن کاملChelidonium majus--an integrative review: traditional knowledge versus modern findings.
Chelidonium majus L. (family Papaveraceae), or greater celandine, is an important plant in western phytotherapy and in traditional Chinese medicine. Crude extracts of C. majus as well as purified compounds derived from it exhibit a broad spectrum of biological activities (antiinflammatory, antimicrobial, antitumoral, analgesic, hepatoprotective) that support some of the traditional uses of C. m...
متن کاملChelidonium majus L. extract induces apoptosis through caspase activity via MAPK-independent NF-κB signaling in human epidermoid carcinoma A431 cells.
Chelidonium majus L. (C. majus L.) is known to possess certain biological properties such as anti-inflammatory, antimicrobial, antiviral and antitumor activities. We investigated the effects of C. majus L. extract on human epidermoid carcinoma A431 cells through multiple mechanisms, including induction of cell cycle arrest, activation of the caspase-dependent pathway, blocking of nuclear factor...
متن کاملAssessment of antioxidant and antibacterial activities of Zinc Oxide nanoparticles, Graphene and Graphene decorated by Zinc Oxide nanoparticles
Zinc Oxide nanoparticles (ZnO-NPs) and graphene carbon material, due to lower drug resistance, can replace antibiotics, and by decorating of graphene with Zn-NPs, their properties can be greatly improved. The purpose of this study was to evaluate the antioxidant and antibacterial effects of ZnO-NPs biosynthesized using Crocus Sativus petal extract, graphene and graphene decorated by ZnO-NPs bio...
متن کامل